BDBM322761 2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[4,5-d]pyridazin-4-yl) amino)phenyl)piperidin-4-yl) cyclopropanecarboxylic acid::US10183944, Example 131::US10647720, Ex. # 131

SMILES OC(=O)C1CC1C1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322761   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322761(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322761(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent